How do I relocate and leave my Family and my child who 17 and lives with her father,?

I have an ailing Father and Mother, a daughter who does not live with me full time and has one more year before college, to move 1100 miles away for a love interest? I have been all over the world, and at many times have lived away for periods of time. I have always had my home to come back too. I have found someone who is much like myself, and get along with very well. He is 56, I am 48. He has great character and is established with a beautiful home in Upstate New York. We have the potential to have a wonderful life together, but I am struggling with leaving my loved ones. He is not the typical person I would be attracted too, but is actually very good for me. My sister's seem to think I would make a mistake in moving because they don't think I would like living there. I have spent a lot of time looking for what this man has to offer for the both of us, and feel that if I don't go, I may have ped up on the opportunity of a lifetime. I will not be able to transfer with my company and will have to seek new employement, but am a very likeable person with many years of experience, so the job thing is not that big of an issue, other than if it doesn't work out, I will have lost a good job and will have to look for work again at my age.I guess my fears are that, I will leave my home town of familiarity, a good job, my daughter who is about to go to college and ailing parents. I have nothing else other than failed relationships and my routine life. I can't shake my feelings of guilt if something should happen to my family and I am not here. I feel this man can offer me the dreams of a life time, but I am not totally in Love with him as of yet. I also feel that if I don't go, I will never find the opportunity again. I am a very attractive person who has never had a problem getting a date, in fact, I have had more than the average bear..my problem is that I have always been searching for more..no one, until now has really gotten my attention. I' m just scared, I guess..to live my life. How do I not feel guilty?